ACE inhibitors are frequently prescribed for high blood pressure. The body’s renin-angiotensin system plays a key role in blood pressure regulation. When the kidneys detect low blood pressure, they release renin, which triggers the formation of angiotensin I. The angiotensin-converting enzyme (ACE) in the lungs then converts angiotensin I into angiotensin II, a potent vasoconstrictor. Angiotensin II causes blood vessels to narrow, increasing blood pressure. ACE inhibitors work by blocking this conversion, preventing the formation of angiotensin II and allowing blood vessels to relax, thus lowering blood pressure. Angiotensin II receptor blockers (ARBs) work by blocking the action of Angiotensin II directly.
Melaleuca’s ProStolic offers a natural approach, featuring bioactive casein hydrolysate tripeptides that act as natural angiotensin II blockers. This proprietary blend also includes pomegranate juice powder, which inhibits ACE activity. Passion flower extract is another key ingredient. While its exact mechanism is still under investigation, researchers believe that flavonoids and alkaloids in passion flower regulate neurotransmitters, reducing anxiety and, consequently, blood pressure. Chrysin, a specific flavonoid, is thought to calm the central nervous system.
ProStolic’s comprehensive formula combines tripeptides, pomegranate juice powder, and passion flower extract with potassium and calcium to promote healthy blood flow and maintain healthy blood pressure naturally, minimizing the side effects often associated with medications. Research indicates that the tripeptides Isoleucine-Proline-Proline (IPP) and Valine-Proline-Proline (VPP), derived from milk casein, exhibit significant efficacy, safety, and bioavailability in supporting healthy blood pressure.
Like ACE inhibitors, these tripeptides block the formation of angiotensin II, preventing blood vessel constriction. However, studies suggest that IPP and VPP achieve this blockage without the common side effects of ACE inhibitors and ARBs. An eight-week, placebo-controlled, double-blind study involving 30 participants with mild to moderate hypertension demonstrated a significant decrease in blood pressure in the IPP and VPP group, with no adverse reactions observed. Further research, including over 20 human clinical trials on IPP and VPP peptides and more than 10 double-blind clinical studies on the specific tripeptide formulation in ProStolic, supports these findings. A 1996 study on elderly hypertensive patients showed a significant decrease in both systolic and diastolic blood pressure after four and eight weeks of tripeptide supplementation, compared to a placebo group.
A British Journal of Nutrition article reported a study of 131 participants that found hydrolyzed casein containing IPP and VPP may assist in preventing hypertension in people with above normal blood pressure.
In addition to tripeptides, Melaleuca’s ProStolic contains pomegranate juice, passion flower, potassium, and calcium to help support healthy blood pressure.